This invention addresses the problem of formulating a pigmentation disorder treatment composition with hydroquinone without an excessive discoloration of the composition in the pH range of about 7.0. 0000002198 00000 n D-170D Solubility of EASTMAN Hydroquinone and Derivatives Subject: Hydroquinone and hydroquinone derivatives listed in this publication are used as intermediates for manufacturing a variety of products and as polymerization inhibitors for vinyl monomers and unsaturated polyester resins. The solubility in water is 6.72g/L. Anal. It is found in wheat, rye, and barley.It is a precursor to diverse industrial products including polymers and plasticizers, as well as being a component of a number of hair and skin conditioners. I did that by using 1 cup of cream, 4tbsp of hydroquinone and 4tbsp of water or solvent. 2023 Springer Nature Switzerland AG. antiphlogistics and cardiaca, Cosmetics or similar toilet preparations characterised by the composition, Cosmetics or similar toilet preparations characterised by the composition containing inorganic ingredients, Sulfur; Selenium; Tellurium; Compounds thereof, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds, Cosmetics or similar toilet preparations characterised by the composition containing organic compounds containing oxygen, . Best Budget Hydroquinone Cream Ambi Skincare Fade Cream (56g/2oz) View on Amazon. 20, 14331442 (1986), G. Wienke, J. Gmehling, Toxicol. endstream endobj 276 0 obj <>stream Thank you for your inquiry and interest in ChemPoint. GHS H Statement: Causes serious eye damage.Suspected of causing genetic defects.May cause an allergic skin reaction.Suspected of causing cancer.Harmful if swallowed.Very toxic to aquatic life. Monobenzone occurs as a white, almost tasteless crystalline powder, soluble in alcohol and practically insoluble in water. Retinoids, in particular retinoic acid, retinal, and their derivatives, isomers and analogs (such as adapalene, tazarotene and isotretoin), are beneficial for improving rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. A2, Designated state(s): S.C. Gad, T. Pham, in Encyclopedia of Toxicology (Third Edition), 2014 Environmental Fate and Behavior. Place water in container then bring the temperature to 15c in a boil bath then add products at this point when youre making the lotion u will need to add the other ingredients. English, J.C. and Deisinger, P.J. The natural pH for conventional hydroquinone compositions is acidic, generally less than about 4 even though this is harsh to the skin and to other components of the product. For a shipping quote, check the box and the bottom and provide us your shipping information. Our team has been notified and we will fix it as soon as possible. Such carriers are widely known in the art and deliver the composition's ingredients to the skin without excessive degradation, inactivation or other unwanted interaction. Retinoids are included from about 0.01% to about 5%, preferably from about 0.025% to about 2%, more preferably 0.05% to about 1.0%, and most preferably from about 0.025% to about 0.5%. The aquatic toxicity of hydroquinone to fresh water fish, Daphnia, and algae was between 0.050- . Thus, merely adding one retinoid to a hydroquinone composition would result in instability and/or discoloration, and adding hydroquinone to a retinoid product would have a similar result. Eng. A common route involves hydroxylation of phenol. D7VJV//KZ&t}JSW/L@,l@^ D@ @8 i W `^;V rD}25p>.Bv1}\_E p9 endstream endobj 392 0 obj 1303 endobj 376 0 obj << /Type /Page /Parent 350 0 R /Resources 377 0 R /Contents 381 0 R /MediaBox [ 0 0 595 842 ] /CropBox [ 0 0 595 842 ] /Rotate 0 >> endobj 377 0 obj << /ProcSet [ /PDF /Text ] /Font << /TT2 379 0 R /TT4 383 0 R /TT6 385 0 R >> /ExtGState << /GS1 387 0 R >> /ColorSpace << /Cs6 378 0 R >> >> endobj 378 0 obj [ /ICCBased 386 0 R ] endobj 379 0 obj << /Type /Font /Subtype /TrueType /FirstChar 32 /LastChar 252 /Widths [ 250 0 408 500 0 833 778 180 333 333 500 564 250 333 250 278 500 500 500 500 500 500 500 500 500 500 278 278 564 564 564 444 921 722 667 667 722 611 556 722 722 333 389 722 611 889 722 722 556 722 667 556 611 722 722 944 722 722 611 333 0 333 0 500 0 444 500 444 500 444 333 500 500 278 278 500 278 778 500 500 500 500 333 389 278 500 500 722 500 500 444 0 0 0 541 0 0 0 0 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 333 0 0 0 500 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 400 0 0 0 0 576 0 0 0 0 0 0 0 750 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 722 0 0 0 0 0 722 0 0 500 444 0 0 0 444 0 0 0 444 444 0 0 0 0 0 0 0 0 0 0 500 0 500 0 0 0 0 0 500 ] /Encoding /WinAnsiEncoding /BaseFont /BCGIOE+TimesNewRoman /FontDescriptor 380 0 R >> endobj 380 0 obj << /Type /FontDescriptor /Ascent 891 /CapHeight 656 /Descent -216 /Flags 34 /FontBBox [ -568 -307 2028 1007 ] /FontName /BCGIOE+TimesNewRoman /ItalicAngle 0 /StemV 94 /XHeight 0 /FontFile2 388 0 R >> endobj 381 0 obj << /Length 462 /Filter /FlateDecode >> stream 115, 22772285 (2014), Article Hydroquinone is highly susceptible to ring substitution by Friedel-Crafts reactions such as alkylation. Skin Contact Wash off immediately with plenty of water for at least 15 minutes. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. If youre making your lotion. Hydroquinone Safety Data Sheet according to Federal Register / Vol. The present invention is not to be limited by any mechanism described in the specification, because it is defined by the claims. Keywords: D-170D; D-170; D170D; D170 Created Date V)gB0iW8#8w8_QQj@&A)/g>'K t;\ $FZUn(4T%)0C&Zi8bxEB;PAom?W= [21][25][23] NTP evaluation showed some evidence of long-term carcinogenic and genotoxic effects[26], While hydroquinone remains widely prescribed for treatment of hyperpigmentation, questions raised about its safety profile by regulatory agencies in the EU, Japan, and USA encourage the search for other agents with comparable efficacy. Production of Hydroquinone Industrial production of hydroquinone usually happens in two ways. 38, 40814091 (1999), J. Qingzhu, M. Peisheng, Y. Shouzhi, W. Qiang, W. Chang, L. Guiju, J. Chem. Approximate Solubilities of USP and NF Articles, methanol, 13; ethyl acetate, >10,000; hexanes, >10,000, 0.1 N hydrochloric acid, 1; 0.1 N sodium hydroxide, 1, boiling alcohol, 50; boiling chloroform, 80; acetone at 50, methanol, 3; isopropanol, 69; benzene, 2500; petroleum ether, 5000, dimethylformamide, 10; 10 N sodium hydroxide, 3.5, dimethylacetamide, 2; dimethylformamide, 3.5; dimethylsulfoxide, 3.5, 0.1 N hydrochloric acid, 2500; 0.1 N sodium hydroxide, 100, isopropyl alcohol, 4; propylene glycol, 9; methanol, 5.3, isopropyl alcohol, 1408; propylene glycol, 119; methanol, 75, alcohol solution (1 in 2), 2; diethylphthalate, <1; benzyl benzoate, <1, acetone, 100; methanol, 1000; 0.1 N hydrochloride acid, >1000, absolute alcohol, 8; methanol, 8; propylene glycol, 19, pyridine, 10; methanol, 71; acetone, 130; methylene chloride, 286; toluene, 2000; dioxane, 2000, carbon disulfide, 2 (slowly and usually incompletely), carbon disulfide, 2 (slowly and usually incompletely) olive oil, 100, methylenedichloride, 43; 4-methyl-2-pentanone, 100. Toughness of the polymer increases due to the presence of flexible units in the backbone such as long chain diols (e.g., diethylene glycol, dipropylene glycol, triethylene glycol) or long chain saturated acids (e.g., adipic . SAS Anti-ox booster 1% 0.3g. International Journal of Thermophysics Stir until uniform. Eng. 0000008514 00000 n 43, 13111316 (2007), J. Qing-Zhu, M. Pei-Sheng, Z. Huan, X. Shu-Qian, W. Qiang, Q. Yan, Fluid Phase Equilib. So, does anybody know of another solvent I could use that has a higher solubility and is relatively non-toxic. 2008-2023 ChemPoint. Phase B: Dissolve the ferulic acid in the glycerin - some "spirited" stirring may be necessary. . The protective system can be an entrapment system, a single or multi- laminar system, such as by the formation of vesicles such as a liposome or by utilizing wax, paraffin, silicone, polyethylene, or any material or system which protects the retinoid from oxidation. 0000085850 00000 n It exerts a depigmenting effect on skin of mammals by increasing the excretion of melanin from the melanocytes. While patients suffer from pigmentation disorders, they may also suffer from other skin disorders and signs of aging, including but not limited to rough skin texture, mottled pigmentation, sallow complexion, lines and wrinkles. The experimental solubilities were correlated using two regression equations. Eastman has active ingredients, thickeners, plasticizers, film formers, and more for your personal care formulations. Data 53, 199200 (2008), N. Sunsandee, S. Suren, N. Leepipatpiboon, M. Hronec, U. Pancharoen, Fluid Phase Equilib. The information given is designed only as a guide for safe handling and use. In hydroquinone and sodium metabisulfite compositions, it is believed that the sodium metabisulfite oxidizes first and delays the start of any oxidation of the hydroquinone, so that excessive discoloration is delayed or totally avoided. 552591, Z. Esina, M. Korchuganova, Theor. Hydroquinone is a white crystalline solid, poorly soluble in water, but more soluble in organic solvents. Adobe Acrobat 10.1.6 Paper Capture Plug-in By acting as a free radical scavenger, hydroquinone serves to prolong the shelflife of light-sensitive resins such as preceramic polymers.[18]. New experimental data are provided for the solubility of resorcinol in water and salicylic acid, resorcinol, hydroquinone in 1-octanol. 65, 5786 (1998), Y.-H. Zhang, Trends Analyt. In another embodiment of the invention, hydroquinone and a protected retinoid are both combined in the composition. Eastman Hydroquinone, USP Grade is for skin-lightening products to address hyperpigmentation. I would like to add retinol and kojic acid to it as well. 109. Then add it to the ingredients. Hydroquinone is combustible when preheated. This Thermo Scientific Chemicals brand product was originally part of the Acros Organics product portfolio. 420, 2429 (2016), W. E. Acree Jr, Thermochim Acta 189, 3756 (1991), F. L. Nordstrm, . C. Rasmuson, J. Chem. Methods and products for nucleic acid production and delivery, Nucleic acid product and its administration method, Nucleic acid product and method of administration thereof, Compositions and systems for the treatment of hyperpigmentation, Methods for prevention of post-inflammatory hyperpigmentation, Skin care compositions containing retinoids, Improved method for stability of ageing comprising thirosinase inhibitor activity, Use of ascorbic acid to reduce irritation of topically applied active ingredients, COSMETIC COMPOSITIONS WITH ANTIMICOTIC PROPERTIES, EFFECTIVE AGAINST PSORIASIS AND HAIR LOSS AND COSMETIC METHOD FOR, Treatment or prevention of undesired skin pigmentation, Skin care compositions and method of improving skin appearance, Ultrasound enhancement of percutaneous drug absorption, Skin whiteners containing hydroxytetronic acid, Stabilized retinoid-containing skin care compositions, Retinoid compositions containing a water soluble antioxidant and a chelator, Composition and method for treating rosacea and sensitive skin with free radical scavengers, Skin care compositions containing imidazoles and retinoids, Stable compositions containing a retinoid and an enzyme based antioxidant system, Self-tanning compositions containing dha and propolis extract, Composition and process for stabilizing oxygen-unstable species, Bleaching preparation and cosmetic for preventing and improving aging of skin, Composition and method for the treatment of pigmentation disorders, Composition for cosmetic or pharmaceutical use, Remedies for pigmentation and melanocyte proliferation inhibitors, Public reference made under article 153(3) epc to a published international application that has entered the european phase, Divisional application: reference to earlier application, Information on the status of an ep patent application or granted ep patent.